Index to Chiropractic Literature
Index to Chiropractic Literature
My ICL     Sign In
Tuesday, May 24, 2022
Index to Chiropractic LiteratureIndex to Chiropractic LiteratureIndex to Chiropractic Literature

For best results switch to Advanced Search.
Article Detail
Return to Search Results
ID 26712
  Title Biochemical & endocrinological changes due to neuropathologic states that can lead to gentoxic consequences: A testable hypothesis for health effects induced by spinal pathomechanics
Journal J Philos Princ Pract Chiropr. 2020 March;():37-52
Peer Review Yes
Publication Type Article

Anatomical, histopathological and neuropathological consequences of spinal cord injury have been reviewed previously. The present review concentrates on literature published since then, and is particularly concerned with the molecular events following spinal cord injury, with the emphasis on such events that relate to genotoxicity. Modern theories relating to oncogenes, to initiation and promotion, and to co-carcinogens are dealt with. There is overwhelming evidence in the literature for the role of hormones in the etiology of cancer.

As co-carcinogens, or agents of promotion, hormones have a prominent role in tumorigenesis through their influence on cellular environment and on the expression of growth capacity. In addition, some writers have suggested that hormones may also be important as initiators of neoplasia as well as being promoters of neoplasia initiated by other agents.

Because of the chronic nature of the results of many spinal injuries, to whatever degree of debilitation, the impact of stress on the human organism must be considered. Hormonal changes elicited by physical and psychological stress are summarized. While pain is included in the general context of stress, it is also treated from other viewpoints: recent literature on pain perception, on endogenous opiates, and on pain control are included in the review. In addition, attention is drawn to the side effects of some drugs, including analgesics as it is clear that some drugs are closely connected with carcinogenesis.

Author keywords: chiropractic, subluxation, adjustment, manipulation, oncogenes, stress, immunity, cancer, mutageneis, neuropathophysiology

Publication Note: This paper is a reprint of the original with the addition of an abstract and key words.

This abstract is reproduced with the permission of the publisher. Full text is available by subscription. Online access only.


   Text (Citation) Tagged (Export) Excel
Email To
HTML Text     Excel

To use this feature you must register a personal account in My ICL. Registration is free! In My ICL you can save your ICL searches in My Searches, and you can save search results in My Collections. Be sure to use the Held Citations feature to collect citations from an entire search session. Read more search tips.

Sign Into Existing My ICL Account    |    Register A New My ICL Account
Search Tips
  • Enclose phrases in "quotation marks".  Examples: "low back pain", "evidence-based"
  • Retrieve all forms of a word with an asterisk*, also called a wildcard or truncation.  Example: chiropract* retrieves chiropractic, chiropractor, chiropractors
  • Register an account in My ICL to save search histories (My Searches) and collections of records (My Collections)
Advanced Search Tips