The brain is the third most nutrient ― and energy-dependent organ in the body, behind only the heart and the kidneys. It is also the most defenseless organ in the body against chemical and emotional toxins, pathogens and emotional and physical trauma. Adequate nutrition plays an important role in the maintenance, treatment and prevention of age-associated brain degeneration (AABD). Malnutrition is amongst the risk factors associated with developing mild cognitive impairment (MCI), dementia, and Alzheimer's disease (AD). Epidemiological studies have associated deficiencies in some nutrients with a higher risk of cognitive dysfunction and/or AD. When it comes to brain function, the good news about dietary supplements is running neck-and-neck with that related to exercise. Cognitive decline in AABD is correlated with synaptic loss; many of the components required to maintain optimal synaptic function are derived from dietary sources. As synapses are part of the neuronal membrane and are continuously being remodeled, sufficient nutrient building blocks (i.e. uridine monophosphate, choline and omega-3 fatty acids) are necessary to make the phospholipids required to minimize synaptic degeneration. In addition, B vitamins, phospholipids and other micronutrients act as cofactors or precursors and are required to make neural cell membrances and synapses. While single supplements may have benefits, a multi-target approach using combinations of (micro)nutrients benefits cognitive function in AABD. This paper is a review of the evidence regarding supplementation. While diet and supplements are a good treatment approach, systemic dysregulation can still occur if metabolic challenges are not addressed. Te most recent research reveals how these natural supplements are revolutionizing brain health support.
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