According to the CDC one or more asthma attacks were experienced by more than half of all asthmatic children in 2016. There seems to be a correlation between vitamin D levels and the incidence of asthma in children. An analysis of ten studies, conducted by Zhang et. al in 2014, showed that, compared to control subjects, cases had significantly higher levels of vitamin D deficiency (60% vs 32%). This study found that the lung function of asthmatic children was significantly reduced by vitamin D deficiency and there was a strong association between lung function and vitamin D status in asthma patients. An analysis of 23 observational studies was published in 2017 by Jat, et al. This study showed that among children with asthma, 28.5% were deficient in vitamin D, and 26.7% were insufficient. Compared with children who are not asthmatic, asthmatic children had lower 35 (OH) D levels. According to Shen, et al., 33 cohort studies were systematically reviewed and meta-analyzed in 2018. Children with asthma or wheeze > 5 years may benefit from antenatal vitamin D intake, according to the analysis of pooled estimates from cohort studies. In 2021, Shi, et al., published a systematic review and meta-analysis of ten articles. This study concluded that women who supplemented with vitamin D during pregnancy had a lower risk of asthma in their infants than those who did not. Infant wheeze had an odds ratio of 0.65, and asthma had an odds ratio of 0.78.
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