Index to Chiropractic Literature
Index to Chiropractic Literature
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Monday, January 25, 2021
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ID 26000
  Title Are chronic inflammation and its metabolic counterpart, insulin resistance, the common denominators for all chronic behavior and neurodegenerative disorders? A review of the evidence - Part VI. Depression - Does research that downplays the kynurenine pathway connection in fact reflect suboptimal nutrient status?
Journal Nutr Perspect. 2019 Oct;42(4):20-22, 24-28
Peer Review No
Publication Type Review

Much of part V of this series focues on research which provided strong support for the hypothesis that chronic inflammation creates depression via alterations in tryptophan metabolism that redirect tryptophan away from serotonin and melatonin production and towards the kynurenine pathway and neuroexcitatory and neurodestructive metabolites such as quinolinic acid that are products of this pathway.  However, while the body of research supporting this connection is immense, it is not unanimous.  What follows next is a review of some fascinating research that suggests the papers arguing against the depression/kynurenine pathway connection are flawed because of a variable that was not controlled for in the populations studied, nutritional status.  As you will see, nutritional status, in fact, has a massive impact on both kynurenine metabolism and clinical depression.

This abstract is reproduced with the permission of the publisher.  Full text is available with membership in the American Chiropractic Association, Council on Nutrition, or through CINAHL (EBSCOhost).


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