An experiment was conducted on laboratory animals (mice) to effect and compare altered electrical responsiveness of nerve roots by subtle, repeated and isolated mechanical irritation, and chemically induced, harsh, acute inflammation. The purpose of this study was to provide data applicable to understanding conditions believed to exist in such compression neuropathies as hypothesized in the chiropractic subluxation "syndrome;" such data not generally being inherent in most previous studies involving acute neural insult. Intermittant irritation of the sciatic nerves of the mice by soft mechanical impant, causing non-degenerative inflammatory changes, resulted in decreased nerve conduction velocity and progressive facilitation during early refractory periods. This observation was concluded to be consistent with human and animal models of compression neuropathy and it is suggested that further investigation of such subtle, mechanical irritation effects upon nerves seems merited.
Author keywords: chiropractic subluxation syndrome, compression neuropathies, decreased nerve conduction velocity, facilitation
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