Index to Chiropractic Literature
Index to Chiropractic Literature
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Monday, January 24, 2022
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ID 24520
  Title Clinical presentation of neurologic manifestations secondary to Leigh disease: A chiropractic case report
Journal J Clin Chiropr Pediatr. 2016 May;15(2):Online access only 1258-1260
Peer Review Yes
Publication Type Case Report

Objective: To raise awareness and assist in recognizing the signs of neurodegenerative disorders as they are presented in a chiropractic office for assessment. This report addresses the clinical presentation, neurologic examination and a discussion about the clinical detection of neurodegenerative disorders in children.

Clinical Features: A case of Leigh disease in a 4-month-old boy. Chiropractic care was sought for gastroesophageal reflux and difficulty feeding. Physical examination revealed hypotonia, developmental delay and abnormal cranial nerve function.

Intervention and Outcome: Due to neurologic presentation, an immediate referral for medical evaluation was done. The child was diagnosed with Leigh disease and passed away one month later. Discussion: Leigh syndrome is a heterogeneous and progressive neurodegenerative disorder of infancy and childhood caused by a mitochondrial dysfunction. Central hypotonia, developmental regression or arrest, and signs of brainstem or basal ganglia involvement (respiratory and ophthalmologic abnormalities, dysphagia, ataxia, dystonia and seizures) are a classical presentation.
This inherited disease is fatal and rapid medical referral is required for patients presenting this condition.

Conclusion: Chiropractors should obtain a precise case history and perform a complete physical and neurological examination to investigate for neurodevelopmental delay or regression. Neurologic abnormalities should be quickly referred for medical investigation to identify the underlying condition.

This abstract is reproduced with the permission of the publisher. Click on the above link for free full text.


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