Index to Chiropractic Literature
Index to Chiropractic Literature
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ID 23744
  Title The cellular and molecular biology of the intervertebral disc: A clinician's primer
Journal J Can Chiropr Assoc. 2014 Sep;58(3):246–257
Peer Review Yes
Publication Type Article

Clinicians routinely encounter patients suffering from both degenerative and acute spinal pain, often as a consequence of pathology affecting the intervertebral disc (IVD). The IVD is a complex structure essential to spinal function and is subject to degenerative disease and injury. However, due to the complexity of spinal pain syndromes it is often difficult to determine the extent of the IVD's contribution to the genesis of spinal pain. The location of the IVD is within close proximity to vital neural elements and may in the event of pathological change or injury compromise those structures. It is therefore important that clinicians performing manual therapy understand the cellular and molecular biology of the IVD as well as its clinical manifestation of degeneration/injury in order to safely manage and appreciate the role played by the disc in the development of mechanical spinal pain syndromes.

Les cliniciens voient régulièrement des patients souffrant de douleurs vertébrales à la fois dégénératives et aiguës, souvent une conséquence d’une pathologie affectant le disque intervertébral (DIV). Le DIV est une structure complexe essentielle à la fonction rachidienne et peut être touché par des maladies dégénératives et des blessures. Toutefois, en raison de la complexité des syndromes de douleurs vertébrales, il est souvent difficile de déterminer la part de contribution du DIV à la genèse de cette douleur. L’emplacement du DIV est à proximité d’éléments neuronaux vitaux et peut, en cas de changement pathologique ou d’une blessure, compromettre ces structures. Il est donc important que les cliniciens administrant une thérapie manuelle comprennent la biologie cellulaire et moléculaire du DIV ainsi que la manifestation clinique de la dégénérescence et des blessures de celui-ci, afin de gérer en toute sécurité et d’apprécier le rôle joué par le disque dans le développement des syndromes de douleurs vertébrales mécaniques.

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