Index to Chiropractic Literature
Index to Chiropractic Literature
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ID 21771
  Title Headache: The placebo effects in the control groups in randomized clinical trials; An analysis of systematic reviews
URL http://www.ncbi.nlm.nih.gov/pubmed/21640253
Journal J Manipulative Physiol Ther. 2011 Jun;34(5):297-305
Author(s)
Subject(s)
Peer Review Yes
Publication Type Article
Abstract/Notes Objective: The purpose of this study is to describe the effects in the placebo and “no treatment” arms in trials with headache patients.

Method: This is a secondary analysis of randomized controlled trials from 8 systematic reviews and selected trials with a “no treatment” or placebo control group. The different types of “no treatment” and placebo interventions were assessed and classified into 6 subgroups. The analyses were carried out according to type of outcome variable.

Results: In total, 119 studies were included (7119 participants). The mean recovery rate in all control groups was 35.7%. Significantly more participants recovered in control groups of pharmacological studies than in nonpharmacological studies: 38.5% vs 15.0%, respectively. Adults were more likely to recover in nonpharmacological studies and children in pharmacological studies.

Conclusions: The mean recovery rate in the control groups was 36%. The recovery rate varied substantially between type of intervention and patients.

This abstract is reproduced with the permission of the publisher; full text by subscription. Click on the above link and select a publisher from PubMed's LinkOut feature.
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