Index to Chiropractic Literature
Index to Chiropractic Literature
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ID 20912
  Title The effect of a colostrum extract of proline rich polypeptides (PRP) on immune status in guinea pigs and its implications on the potential of PRP in aging humans
Journal Nutr Perspect. 2009 Apr;32(2):25-31
Peer Review No
Publication Type Article
Abstract/Notes To demonstrate the efficacy of PRP in down regulating Th2 dominance an experiment was performed on guinea pigs sensitized to egg protein. Exposure to egg protein resulted in development of acute phase bronchial spastic reaction in 100% of animals, 3 of 6 (50%) of whom died quickly from suffocation. The duration of acute phase and sub-acute phase in the three surviving animals was 14.3 minutes on average. Introduction of PRP prior to egg protein inhalation resulted in death of only 2 animals out 7 (28.6%). Development of acute bronchial spastic reaction on exposure to the antigen was present in 2 (40%) of the 5 surviving animals, but averaged only 16 seconds. None (0%) of the survivors experienced any sub-acute phase reactions. A similar model was employed using histamine as the initiator of bronchial spasm, with similar, though non- fatal symptoms. In this histamine model, pre-treatment with PRP had no effect. This supports the notion that any effectiveness of PRP pre-treatment was not related to an inherent anti-histamine effect. In humans the thymus is very sensitive to stress hormones (cortisol) which promote Th2 dominance, precipitating allergic and autoimmune reactions, while down regulating Thl immunity, favoring infection and tumor growth proliferation. With aging, Cortisol / DHEA ratios favor cortisol over DHEA, leading to a similar immune imbalance. Furthermore, thymopoiesis is diminished with diminishing growth hormone (GH) secretion, which itself is diminished with aging.

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