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Index to Chiropractic Literature
Index to Chiropractic Literature
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ID 20722
  Title Reduction in high blood tumor necrosis factor-á levels after manipulative therapy in 2 cervicogenic headache patients [case report]
URL http://www.ncbi.nlm.nih.gov/pubmed/19748410
Journal J Manipulative Physiol Ther. 2009 Sep;32(7):586-591
Author(s)
Subject(s)
Peer Review Yes
Publication Type Case Report
Abstract/Notes Objective: This case report discusses the treatment of 2 patients with cervicogenic headache (CHA) attending the Outpatient Clinic of the Hungarian National Institute for Rheumatology and Physiotherapy (Budapest, Hungary) and reviews the pathophysiology, therapeutic strategy, and problems associated with the treatment of CHA.

Clinical Features: Patient 1 was a 27-year-old female who sustained a whiplash injury. A sharp, shooting headache developed, readily induced, and aggravated by just bending the neck backward or by turning her head. Magnetic resonance imaging revealed a disk protrusion at C4-C5 pressing the anterior cerebrospinal space. Patient 2 was a 62-year-old female who sustained a whiplash injury; her cervical movements became restricted, which precipitated headaches. Magnetic resonance imaging revealed a paramedian disk hernia between the C4 and C5 vertebrae that intruded into the right ventral cerebrospinal space.

Intervention and Outcome: After 4 weeks of manipulative therapy for patient 1, both active and passive range of motion returned to normal, and the high tumor necrosis factor-á (TNF-á) level (63 pg/mL) was substantially reduced (28 pg/mL). Patient 2 was started on manipulative therapy twice a week for 4 weeks; after 2 months, the patient became symptom-free, and high TNF-á level (72 pg/mL) was reduced greatly (35 pg/mL).

Conclusion: Two patients with whiplash injury and disk herniation developed CHA associated with very high TNF-á levels. After manipulative therapy, these patients became symptom-free, and their TNF-á levels decreased substantially.

This abstract is reproduced with the permission of the publisher. Click on the above link for the PubMed record for this document; full text by subscription. Select a publisher from PubMed's Links>>Linkout


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