Time-force analyses show that most chiropractic adjustments are characterised by a high velocity
thrust followed by a period of maintained force. This is likely to result in an initial passive stretch of muscle around the joint followed by a longer eccentric stretch. Recently, we found that eccentric muscle stretch is a powerful stimulus for production of a novel splice variant of insulin-like growth factor-1 called MGF that promotes the growth, repair and survival of both nerve and muscle. Eccentric muscle stretch as a result of the chiropractic adjustment could therefore upregulate MGF resulting in
local myotrophic and neurotrophic effects. Acknowledgments: Published work supported by the MRC, BBSRC and Wellcome Trust.
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