The effects of the anti-inflammatory agent dexamethasone (dex), on lymphocyte biosynthesis were investigated by monitoring the activity of the rate-controlling enzyme of polyamine metabolism. A marked negative growth response was observed as early as 2 hours after dex treatment. This effect was found to be specific for lymphatic tissue, for the enzymes associated with polyamine biosynthesis and resulting only from dexamethasone, a cortisol analog, and not from other hormones.
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