Index to Chiropractic Literature
Index to Chiropractic Literature
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ID 11749
  Title Proteoglycans and degenerative spondylosis
Journal J Manipulative Physiol Ther. 1988 Feb;11(1):36-40
Peer Review Yes
Publication Type Article

Proteoglycans are high molecular weight glycoproteins found in connective tissue. They imbibe water into intervertebral disc and apophyseal joint articular cartilage, endowing the tissues with elasticity and compressibility. A decrease in total tissue content of proteoglycans appears to predispose intervertebral disc to degeneration. The earliest tissue changes associated with the onset of spondylosis occur at the molecular level and may include alterations in proteoglycan structure and content. A number of models have been suggested to describe the relationship between changes in proteoglycan composition and degenerative changes in cartilage and intervertebral disc.

This abstract is reproduced with the permission of the publisher. Article only available in print.


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